he book series Integrated Analytical Systems offers the most recent advances in all key aspects of development and applications of modern instrumentation for che- cal and biological analysis. The key development aspects include (i) innovations in sample introduction through micro- and nano?uidic designs, (ii) new types and methods of fabrication of physical transducers and ion detectors, (iii) materials for sensors that became available due to the breakthroughs in biology, combinatorial materials science, and nanotechnology, and (iv) innovative data processing and mining methodologies that provide dramatically reduced rates of false alarms.